SPAR, a lncRNA encoded mTORC1 inhibitor

A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma.

Although signaling from phosphatidylinositol 3-kinase (PI3K) and AKT to mechanistic target of rapamycin (mTOR) is prominently dysregulated in high-grade glial brain tumors, blockade of PI3K or AKT minimally affects downstream mTOR activity in glioma. Allosteric mTOR inhibitors, such as rapamycin, incompletely block mTORC1 compared with mTOR kinase inhibitors (TORKi). Here, we compared RapaLink-...

The Varicellovirus-encoded Tap Inhibitor

Task Parallelism in Spar

In this paper we will give a small introduction to Spar, a programming language for semi-automatic parallel programming. Spar, a Java derivative is being developed as part of the Automap project, which aims to create completely automatic mappings for code and data at either compile time or runtime. We will present how Spar supports task-parallel programming and how it interacts with the user or...

SPAR: a schematic place and route system

This paper presents an approach to the automatic generation of schematic diagrams from circuit descriptions. The heuristics which make up the system are based on two principles of schematics readability: Functional Identi cation and Traceability. SPAR's generation process is broken into ve distinct phases: partitioning the netlist, placement of components on the page, global routing, local rout...

The Spar/Java Programming Language

In recent years, embedded systems with multiple processors have become increasingly important. These systems often consistof a general-purpose processor and one, oreven several, digital signal processors (DSPs). For portability, flexibility, and robustness it is often useful to regard such a cluster as a single, parallel, system. Since such a system contains several types of processors, it is s...